Technologies

Pulsed ESR: Distance Measurements in proteins and aggregates using double electron-electron resonance (DEER) and double quantum coherence (DQC) ESR, to advance our knowledge of structure and function of biomolecules using longer distance constraints, provided by site-directed spin labeling and pulsed ESR distance measurements.

Pulsed ESR: pulsed 2D Fourier transform ESR , to apply 2D-ELDOR in the study of the dynamic structure of membranes and of proteins, as well as lipid-protein interactions.

ESR with Ultra-High Sensitivity for Very Small Biological Samples , for biomedical studies of tissues, cells and other bio-samples with micron resolution.

HFHF ESR: continuous-wave, quasi-optical techniques for HFHF-ESR to unravel the complex dynamics in biological systems and, especially, high power pulsed ESR in the mm-wave regime, to benefit from the improved orientational resolution and faster "snapshot" feature at higher frequencies.

HFHF ESR: time-domain , quasi-optical techniques for HFHF-ESR to unravel the complex dynamicsin biological systems and, especially, high power pulsed ESR in the mm-wave regime, to benefit from the improved orientational resolution and faster "snapshot" feature at higher frequencies.

Multifrequency Studies , to advance knowledge of dynamics in proteins, DNA, and membranes by a mixture of multifrequency and multidimensional ESR.

Protein Dynamics by NMR

Model and Cell Membrane Dynamics by ESR

Theory and computational methods , for interpreting multifrequency spectra in terms of powerful algorithms based on the stochastic Liouville equation and on molecular dynamics simulations.

Denoising of ESR Spectra, and Distance Measurements using our latest wavelet denoising methods to obtain signals with high SNR from weaker experimental signals.

ACERT's Service and Collaborative Projects cover a wide range of biomedical research areas, emphasizing the
central role that modern ESR methods can play in contemporary biomedical
sciences.

Past Technology Achievements of ACERT while a P41 Technology Development Center